痛风及高尿酸血症的发病机制研究进展(3)

　　3.小结

　　近年来，随着人们生活水平的提高和生活方式的改变，痛风性关节炎发病率逐年提高，发病年龄也逐渐提前。痛风及高尿酸血症的发病机制与尿酸代谢的生理生化息息相关，也与免疫学有密切联系。尿酸代谢与两方面相关，生成过多由嘌呤代谢酶的缺乏所造成，排泄减少主要是由于肾小管和肾小球上存在参与尿酸排泄的重要转运体，其异常影响尿酸排泄。目前大多数对痛风的研究都局限于尿酸代谢异常，而尿酸盐触发痛风炎症反应的具体发病机制尚未完全明确。随着医学知识的不断深入发展，免疫与炎症在痛风发病机制中的作用也逐渐受到医学科研工作者的关注,其具体机制有待于进一步研究。

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